CSCE 355: Foundations of Computation

Project Report for CSCE 821 Submitted

Interlaboratory diagnostic validation of conformation-sensitive capillary electrophoresis for mutation scanning.

BACKGROUND Indirect alternatives to sequencing as a method for mutation scanning are of interest to diagnostic laboratories because they have the potential for considerable savings in both time and costs. Ideally, such methods should be simple, rapid, and highly sensitive, and they should be validated formally to a very high standard. Currently, most reported methods lack one or more of these c...

CSCE 750: Analysis of Algorithms Course Notes

Design and validation of a conformation sensitive capillary electrophoresis-based mutation scanning system and automated data analysis of the more than 15 kbp-spanning coding sequence of the SACS gene.

In this study, we developed and analytically validated a fully automated, robust confirmation sensitive capillary electrophoresis (CSCE) method to perform mutation scanning of the large SACS gene. This method facilitates a rapid and cost-effective molecular diagnosis of autosomal recessive spastic ataxia of Charlevoix-Saguenay. Critical issues addressed during the development of the CSCE system...

Stability and vibration analyses of tapered columns resting on one or two-parameter elastic foundations

This paper presents a generalized numerical method to evaluate element stiffness matrices needed for the free vibration and stability analyses of non-prismatic columns resting on one- or two-parameter elastic foundations and subjected to variable axial load. For this purpose, power series approximation is used to solve the fourth–order differential equation of non-prismatic columns with v...